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Does Mannose-Binding Lectin Gene Polymorphism in Pediatric Patients Undergoing Peritoneal Dialysis Cause Susceptibility to the Development of Peritonitis? [Behcet Uz Cocuk Hast Derg]
Behcet Uz Cocuk Hast Derg. 2021; 11(2): 133-138 | DOI: 10.5222/buchd.2021.57767  

Does Mannose-Binding Lectin Gene Polymorphism in Pediatric Patients Undergoing Peritoneal Dialysis Cause Susceptibility to the Development of Peritonitis?

Gültaç Evren1, Mustafa Bak2, Erkin Serdaroglu2, Burak Durmaz3, Ferda Özkınay3
1Department Of Pediatric Intensive Care Unit, Faculty Of Medicine Dokuz Eylul University, Izmir, Turkey
2Department Of Pediatric Nephrology, Dr. Behcet Uz Children’s Hospital, University Of Health Sciences, Izmir, Turkey
3Departments Of Medical Genetics, Faculty Of Medicine Ege University, Izmir, Turkey

Objective: This study aims to investigate the relationship between peritonitis attacks and mannose-binding lectin (MBL) gene polymorphism in patients undergoing peritoneal dialysis.
Method: Codon 54 polymorphism found in exon 1 of the MBL gene was investigated by polymerase chain reaction-restriction fragment length polymorphism method in 45 patients with chronic renal failure undergoing peritoneal dialysis.
Results: The frequency of the mutant B allele was not significantly higher in the patient group (4.4%) than the control group (2.1%). The AB genotype was found at a rate of 15.6% and 34% in the patient group and healthy control group, respectively. The AA genotype was found in 80% of children who underwent peritoneal dialysis and 63.8% of the healthy control group.
Conclusion: In our study, no relationship was found between peritonitis attacks and MBL gene polymorphism in patients undergoing peritoneal dialysis.

Keywords: peritoneal dialysis, peritonitis, mannose-binding lectin, PCR


Periton Diyalizi Yapılan Çocuk Hastalarda Mannoz Bağlayan Lektin Gen Polimorfizmi, Peritonit Gelişimine Yatkınlık Oluşturur mu?

Gültaç Evren1, Mustafa Bak2, Erkin Serdaroglu2, Burak Durmaz3, Ferda Özkınay3
1Çocuk Yoğun Bakım Ünitesi, Dokuz Eylül Üniversite Hastanesi, İzmir, Türkiye
2Çocuk Nefroloji, S.b.ü Dr. Behçet Uz Çocuk Hastalıkları Ve Cerrahisi Eğitim Ve Araştırma Hastanesi, İzmir, Türkiye
3Medikal Genetik, Ege Üniversitesi Hastanesi, İzmir, Türkiye

Amaç: Bu çalışmada, periton diyalizi yapılan hastalarda peritonit ataklarının mannoz bağlayan lektin (MBL) gen polimorfizimi ile arasındaki ilişki incelenmiştir.
Yöntem: MBL geni ekson 1’inde bulunan Codon 54 polimorfizmi, periton diyalizi yapılan 45 KBY hastasında ve 45 sağlıklı kontrol grubunda polimeraz zincir reaksiyonu kısıtlama fragman uzunluğu polimorfizm yöntemi ile araştırıldı.
Bulgular: Mutant B allel sıklığı hasta grubunda (%4.4) kontrol grubuna (%2.1) göre anlamlı derecede yüksek değildi. AB genotipi, hasta grubunda ve sağlıklı kontrol grubunda sırasıyla %15,6 ve % 34 olarak bulundu. Periton diyalizi yapılan çocukların% 80’inde ve sağlıklı kontrol grubunun %63.8’ünde AA genotipi bulundu.
Sonuç: Çalışmamızda periton diyalizi yapılan hastalarda peritonit atakları ile mannoz bağlayan lektin (MBL) gen polimorfizmi arasındaki ilişki bulunamamıştır.

Anahtar Kelimeler: periton diyalizi, peritonit, Mannoz bağlayan lektin, PCR


Gültaç Evren, Mustafa Bak, Erkin Serdaroglu, Burak Durmaz, Ferda Özkınay. Does Mannose-Binding Lectin Gene Polymorphism in Pediatric Patients Undergoing Peritoneal Dialysis Cause Susceptibility to the Development of Peritonitis?. Behcet Uz Cocuk Hast Derg. 2021; 11(2): 133-138

Corresponding Author: Gültaç Evren, Türkiye


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