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What is the Role of Mannose-Binding Lectin Gene Polymorphism in the Development of Acute Post-Streptococcal Glomerulonephritis? [Behcet Uz Cocuk Hast Derg]
Behcet Uz Cocuk Hast Derg. Ahead of Print: BUCHD-46693 | DOI: 10.5222/buchd.2021.46693  

What is the Role of Mannose-Binding Lectin Gene Polymorphism in the Development of Acute Post-Streptococcal Glomerulonephritis?

Deniz Güven1, Mustafa Bak2, Erkin Serdaroglu3, Ferda Özkınay4, Ayça Aykut5
1University of Health Science, Ankara Keçiören Training and Research Hospital, Department of Pediatrics, Ankara
2Special İzmir Pediatric Nephrology and General Pediatrics Clinic, İzmir
3University of Health Science, İzmir Dr. Behçet Uz Pediatric Disease and Surgery Training and Research Hospital, Department of Pediatric Nephrology, İzmir
4Ege University Faculty of Medicine, Department of Pediatrics, İzmir
5Ege University Faculty of Medicine, Department of Medical Genetics, İzmir

Objective: This study aims to determine the effects of the mannose-binding lectin (MBL) gene polymorphism on the clinical and laboratory findings, response to treatment, and progress of patients with acute post-streptococcal glomerulonephritis (APSGN).
Methods: Codon 54 polymorphism found in exon 1 of the MBL gene was investigated by polymerase chain reaction-restriction fragment length polymorphism method in 110 children followed up with the diagnosis of APSGN and compared with healthy control group.
Results: The normal allele AA and, the variant alleles AB and BB gene frequencies were determined within the APSGN group as 74.5%, 20% and, 5.5%, respectively. No statistically significant difference was found with concerning to the gene polymorphism in the APSGN group when compared with the control group (p>0.05). No correlation was found in the patient group between gene polymorphism and the presence of hematuria, edema, central nervous system findings, and blood pressure (p>0.05). Concerning laboratory findings during the diagnosis, no correlation existed between the gene polymorphism and high levels of urea, creatine, total cholesterol, and triglycerides, low levels of albumin, and the presence of proteinuria (p>0.05). Within the first years following the diagnosis, no statistically significant difference was found in the glomerular filtration rates, blood creatine levels, proteinuria levels, duration of microscopic hematuria and proteinuria between the patients with the gene polymorphism and those without the gene polymorphism (p>0.05)
Conclusion: Our study determined that the MBL gene polymorphism was not important in the development, the laboratory and clinical findings, or the progression of the patients with APSGN.

Keywords: acute post-streptococcal glomerulonephritis, mannose-binding lectin, gene polymorphism, prognosis.


Akut Post Streptokokal Glomerülonefrit Gelişiminde Mannoz-Bağlayıcı Lektinin Rolü Nedir?

Deniz Güven1, Mustafa Bak2, Erkin Serdaroglu3, Ferda Özkınay4, Ayça Aykut5
1SBÜ Ankara Keçiören Eğitim Araştırma Hastanesi, Pediatri Kliniği, Ankara
2Özel İzmir Çocuk Sağlığı ve Çocuk Nefroloji Kliniği, İzmir
3SBÜ İzmir Dr.Behçet Uz Çocuk Hastalıkları ve Cerrahisi Eğitim ve Araştırma Hastanesi, Pediatrik Nefroloji Kliniği, İzmir
4Ege Üniversitesi Tıp Fakültesi, Pediatri Ana Bilim Dalı, İzmir
5Ege Üniversitesi Tıp fakültesi, Genetik Ana Bilim Dalı, İzmir

Amaç: Bu çalışma, mannoz bağlayıcı lektin (MBL) gen polimorfizminin, akut post-streptokokal glomerülonefrit (APSGN) klinik ve laboratuvar bulguları, tedaviye yanıtı ve prognozu üzerindeki etkilerini belirlemeyi amaçlamaktadır.
Yöntem: MBL geninin ekson 1’inde bulunan Codon 54 polimorfizmi, APSGN tanısı ile takip edilen 110 çocukta polimeraz zincir reaksiyon-restriksiyon fragman uzunluğu polimorfizmi yöntemi ile araştırıldı.
Bulgular: APSGN grubunda normal alel AA ve varyant allel AB ve BB gen frekansları sırasıyla %74,5, %20 ve %5,5 olarak belirlendi. Kontrol grubuna göre APSGN grubunda gen polimorfizmi açısından istatistiksel olarak anlamlı ilişki bulunmadı (p>0,05). MBL gen polimorfizmi ile tanı sırasındaki laboratuvar bulguları olan; yüksek üre, kreatin, total kolesterol ve trigliserid düzeyleri, düşük albümin düzeyleri ve proteinüri varlığı arasında ilişki yoktu (p>0,05). Tanıyı takip eden ilk yılda gen polimorfizmi olan ve olmayan hastalar arasında glomerüler filtrasyon oranları, kan kreatin düzeyleri, proteinüri düzeyleri, mikroskobik hematüri ve proteinüri süresi açısından istatistiksel olarak anlamlı fark bulunmadı (p>0,05)
Sonuç: Çalışmamız, MBL gen polimorfizminin APSGN gelişiminde, laboratuvar ve klinik bulgularında ve hastalığın ilerlemesinde önemli olmadığını göstermiştir.

Anahtar Kelimeler: akut post-streptokokal glomerülonefrit, mannoz bağlayıcı lektin, gen polimorfizm, prognoz




Corresponding Author: Deniz Güven, Türkiye


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