Abstract

OBJECTIVE

The studies considering childhood renal disease epidemiology and clinical and histopathological findings are scarce in our country. This study aims to examine the clinical and histopathological profile of the renal biopsies evaluated at the Behcet Uz Children’s Hospital(BUCH)) and determine their status of correlation with clinical diagnosis.

METHODS

The documents of the 123 biopsies executed between 2009-2010 at the BUCH and Izmir Tepecik Training and Research Hospital Child Health Department and evaluated at the Dr. Behcet Uz CDH pathology department were assessed. All patients were considered all clinical characteristics.

RESULTS

The mean age was 9.4±4.0and 52% were females. Among the 170 biyopsy indications the leading one was Nefrotic proteinuria with 51,8 %. Among the 201 clinical diagnosis FSGS was the first in the rank with 25.9%. Mezengioproliferative glomerülonephritis, minimal lesion disease which were considered as normal under light microscope evaluation and the nondiagnosed spesimens which were only reported with their microscopic features were the three leading results of the histopathological evaluations. Clinicopathological correlation was achieved among 86.3% of the patients while this correlation was lost for tubulointersitisyel nephritis and chronic glomerulonephritis cases.

CONCLUSION

In this study the renal biopsy endications are consistent with the literature and nephrotic syndrome, proteinuria and hematuria are the leading endications. Among the nephrotik syndrome group mezengioproliferatif glomerülonefritis and ML disease is predominant while in the hematuria group the leading pathological diagnosis are HSV nefritis and IgA nephropathy. For achiving better clinicopathological correlation, electron microscope evaluation and genetic analysis is necessary.