Abstract

INTRODUCTION

Various factors are responsible for uremic anorexia. Increase in serum leptin levels and uremic toxins stimulate melanocortin hormone receptors to increase energy consumption and reduce food intake. In this study, we compared renal excretion of leptin by comparing serum leptin concentrations of children with chronic renal failure with healthy controls.

METHODS

Serum leptin, leptin / BMI, albumin, glucose, creatinine, urea, triglyceride and cholesterol levels were eveluated in a total of 33 pediatric patients followed up for chronic renal failure and 29 healthy children in the control group.

RESULTS

Serum leptin levels (18,49 ± 28,55) and leptin / BMI (0,94 ± 1,36) in female patients were higher than leptin (7,73 ± 5,65) and leptin / BMI (0,39 ± 0,25) in control group (p> 0,05). In male patients, serum leptin levels (1,48 ± 1,36; 4,88 ± 3,70) and leptin/ BMI (0,08±0,081; 0,25±0,16) were found to be lower than control group (p<0,01). Serum leptin levels showed a significant positive correlation with BMI in chronic renal failure and healthy group in females; there was no correlation between leptin and BMI in the male patient group. There was no correlation between leptin and glomerular filtration rate and serum creatinine levels in all patients except in male dialysis group. There was no correlation between serum leptin levels with age, duration of disease diagnosis, and duration of dialysis.

DISCUSSION AND CONCLUSION

There might be other factors involved in the synthesis or activity of leptin or receptor proteins of it in the role of extrarenal catabolism.