Abstract

INTRODUCTION

Children with a low nephron number have an increased risk of developing hypertension, proteinuria and chronic kidney disease in later life. This renal injury is caused by glomerular hyperfiltration. The aim of this study was to evaluate clinical characteristics and follow-up results of unilateral renal agenesis and hypoplasia of children.

METHODS

We reviewed the clinical, radiological, and nuclear medicine findings of children with unilateral agenetic or hypoplastic kidney who were followed at Celal Bayar University Scholl of Medicine and Dr. Behcet Uz Children's Hospital between 2005 and 2012.

RESULTS

The study was consisted of 30 (60%) males and 20 (40%) females with an average age of 8.9±4 years. A total of 25 patients were diagnosed renal agenesis and 25 were diagnosed with renal hypoplasia. On laboratory evaluation, the mean serum creatinine level was 0.45±0.22 mg/dl and the mean estimated glomerular filtration rate (eGFR) was 144±30.3 ml/min. 29 patient (58%) had hyperfiltration according to an eGFR. Proteinuria and hypertension were noted in 1 (4%). Urological anomalies were found in 15 patients (30%).

DISCUSSION AND CONCLUSION

Our study determines children with unilateral renal agenesis and hyopoplasia had normal serum creatinine values. Howewer 29 patient (58%) had hyperfiltration according to eGFR. Because many children with hiperfiltration develop renal injury in later life, we emphasize the need for clinical follow up in these patients starting at birth.