Does Mannose-Binding Lectin Gene Polymorphism in Pediatric Patients Undergoing Peritoneal Dialysis Cause Susceptibility to the Development of Peritonitis?
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Research Article

Does Mannose-Binding Lectin Gene Polymorphism in Pediatric Patients Undergoing Peritoneal Dialysis Cause Susceptibility to the Development of Peritonitis?

J Behcet Uz Child Hosp 2021;11(2):133-138 DOI: 10.5222/buchd.2021.57767
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Abstract

Objective: This study aims to investigate the relationship between peritonitis attacks and mannose-binding lectin (MBL) gene polymorphism in patients undergoing peritoneal dialysis.

Method: Codon 54 polymorphism found in exon 1 of the MBL gene was investigated by polymerase chain reaction-restriction fragment length polymorphism method in 45 patients with chronic renal failure undergoing peritoneal dialysis.

Results: The frequency of the mutant B allele was not significantly higher in the patient group (4.4%) than the control group (2.1%). The AB genotype was found at a rate of 15.6% and 34% in the patient group and healthy control group, respectively. The AA genotype was found in 80% of children who underwent peritoneal dialysis and 63.8% of the healthy control group.

Conclusion: In our study, no relationship was found between peritonitis attacks and MBL gene polymorphism in patients undergoing peritoneal dialysis.

Keywords: peritoneal dialysis, peritonitis, mannose-binding lectin, PCR