Abstract
INTRODUCTION
Celiac disease with genetic predisposition is more likely to be seen in patients' relatives than in the general population. In this study, it is aimed to evaluate our patients with celiac disease and their siblings in this respect.
METHODS
151 patients who diagnosed and follow-up with celiac disease in our pediatric gastroenterology clinic were evaluated. How many siblings of patients were diagnosed with celiac disease, diagnosis duration between siblings, complaints and celiac serology at the diagnosis, Marsh classifications, human leukocyte antigen (HLA) tissue types were evaluated.
RESULTS
Celiac disease was detected in total 10 siblings of 9(5.96%) patients. The mean age of the patients was 6.9 ± 3.4 years, and the mean age of the siblings were 6.2 ± 4.4 years. Two siblings were diagnosed with celiac disease at the same time, in the other patients, the mean duration of diagnosis between the index cases and the siblings was 29 ± 39.5 months. The most common causes of admission of index cases were abdominal pain and growth retardation, 40% of siblings were asymptomatic. The tissue transglutaminase antibody IgA values of the patients and their siblings at diagnosis were> 200 RU / ml, endomysial antibodies IgA was in 6 of the patients and in 8 of the siblings 1/100 or >1/100. Human leukocyte antigen (HLA) tissue types DQA1*05 and/or DQB1*02 were detected in all patients and their siblings.
DISCUSSION AND CONCLUSION
The siblings of all patients diagnosed with celiac disease need to be screened for celiac disease, even if they are asymptomatic.
Keywords: Celiac disease, siblings, tissue typing, genetics
