Abstract
INTRODUCTION
Neuroblastoma (NB) is the most common extracranial solid cancer in childhood and the most common cancer in infancy. Nearly half of neuroblastoma cases occur in children younger than two years. It is a neuroendocrine tumor, arising from neural crest. It most frequently originates in one of the adrenal glands, but can also develop in nerve tissues in the neck, chest, abdomen, or pelvis. In this study, neuroblastoma cases were reviewed and classified occording to the Shimada classification.
METHODS
49 patients who diagnosed neuroblastoma from 2004 to 2015 were included the study. Tumor size, location, differenation, mitotic caryorrhrtic index and age were evaluated. Tumors were classified to favourable and unfavourable prognostic groups according to the Shimada classification. Log-rank test were used to assess interaction between the Shimada classification and survival.
RESULTS
Of 49 patients in this study, were followed mean 62,9 ± 7,8 months. Thirteen (%26,5) patients were died. According to the Shimada classification, 33 (%67,3) patients were in unfavourable prognostic group, while 16 (%32,7) patients were favourable prognostic group. Survival rate in favourable and unfavourable prognostic groups were %87,5 and %66,7, respectively (p=0.011).
DISCUSSION AND CONCLUSION
Shimada classification was found to be associated with survival.
Keywords: neuroblastoma, Shimada classification, neural crest
