Abstract
Hepatoblastoma is the most common hepatic malignancy in children. In recent years, diagnosis and treatment have been improved in hepatoblastoma, and long survival has become possible. Intraabdominal mass and elevated alpha-fetoprotein level raise suspicion for hepatoblastoma. However, it is important to consider age-appropriate normal values when assessing alpha-fetoprotein levels in infancy. For the diagnostic steps, abdominal ultrasonography, and computerized tomography or magnetic resonance imaging are needed. According to imaging findings, PRETEXT stage should be determined. The appropriate surgical management strategy for hepatic tumors begins at the initial radiological assessment and continues through the biopsy and tumor resection. The International Childhood Liver Tumor Strategy (SIOPEL) Group has been recommending preoperative chemotherapy in order to make the tumor more likely to be safely and completely resected. Liver transplantation must be considered when complete tumor excision by partial hepatectomy is unlikely.
Keywords: Children, hepatoblastoma, pathology, genetics, treatment
