Abstract
OBJECTIVE
We aimed to evaluate the liver biopsy findings of neonatal patients with cholestasis and to determine the prevalence of biliary atresia and neonatal hepatitis.
METHODS
We retrospectively reviewed the liver biopsy findings of 153 newborn (0-4months) patients with neonatal cholestasis between 1992 and 2011 at Izmir Dr.Behcet Uz children’s Hospital. relationship of some parameters such as age, sex and findings of radiological investigations was assessed.
RESULTS
This series consisted of 93 (60.8%) boys and 60 (39.2%) girls with mean age of 73.8±30.5 days (10-120 days). Differential diagnosis was made with only one biopsy in 117 cases (76.5). Histopathologically 82 children (53.6%) were diagnosed as neonatal hepatitis and 71 children (46.4%) as diagnosed as biliary atresia. Kasai operation was performed in 23 children (32.4%) with biliary atresia and transplantation was performed in 11 children (15.4%). There was a relationship between the age of children and diagnosis (p=0.010).
CONCLUSION
In the present study, a realistic comprehensive picture of the liver biopsy findings of newborn babies with neonatal cholestasis was revealed. Then it was discussed the clues of differential diagnosis in these disorders.
Keywords: Neonatal cholestasis, differential diagnosis, liver biopsy findings.
