Abstract
OBJECTIVE
We evaluated the microalbuminuria, excretion of urinary b2-MG and the capacity of renal functional reserve (RFR) in patients with insulin dependent diabetes mellitus (IDDM) that may be important in detecting early renal involvement. We also evaluated the relationship between microalbuminuria, tubular proteinuria, RFR and metabolic control and duration of illness in IDDM. For this purpose, we designed a case control study.
METHODS
Renal functional reserve test was performed in all cases. Levels of peak urinary albumin and b2-MG protein were measured at the beginning of test and after the load of protein.
RESULTS
In the patient group, levels of the mean hemoglobin A1C (HbA1C) level was %11.08±2.47, and the fasting plasma glucose was 249.90±52.6 mg/dL. Maximum glomerular filtration rate (GFR) increasing were 31.95±27.31% in the patients and 49.09±18.99% in the control group. In the patient group, the peak GFR level and the maksimum GFR increasing were statistically significantly lower. In the patient group and control group, there were no statistically difference between the mean basal and peak urinary albumin and b2-MG levels. We detected significant negatif correlation between the duration of illness, HbA1C and peak GFR, maximum GFR increasing (p<0.05). But, we have not found a significant correlation between the duration of illness, HbA1C and urinary albumin, b2-MG.
CONCLUSION
As we have not found a significant diffrenece between the urinary albumin andb2-MG levels in the two goups, and detected lower peak GFR and maximum GFR in the patient group, we suggested that RFR test has a high sensitivity.
Keywords: Insulin Dependent Diabetes Mellitus, capacity of renal functional reserve
